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A central theme running throughout the module will be toxicology: how xenobiotics can be causes or treatments in diseases. The basic principles of toxicokinetics (absorption, distribution, metabolism and excretion) and toxicodynamics (adverse effects in the body) will be explored in relation to named environmental pollutants, occupational hazards, and pharmaceutical agents.
The module will introduce students to the concepts of health and illness, classification of diseases, cell adaptation to disease, inflammation, cell injury/death, and neoplasia. The development of disease will be examined, together with the principles of disease pathogenesis, investigation and treatment.
Case studies of conditions such as diabetes mellitus, hepatitis, COPD and heart failure, will consolidate the related themes of the module.
This module is designed to integrate learning from the different laboratory based biomedical disciplines. You are therefore not expected to learn medical details of all diseases, rather to gain an understanding of a range of disease processes and how these result in measurable outcomes.

Upon completion of this module you will be able to:
LO1: Critically appraise the relationship between absorption, distribution, metabolism and excretion of major drugs and toxicants
LO2: Evaluate the importance and role of dose-response relationships in toxicology and compare the actual risk of a toxicant with the perception of risk, and evaluate associated risk and hazard
LO3: Discriminate pathological processes occurring at molecular, cellular, tissue, organ and system level, including adverse effects of toxicants and ionising radiation
LO4: Critically analyse case studies integrating results of patient investigations and laboratory findings
LO5: Critically assess the investigative and therapeutic approaches applied to the diseases discussed