Core Module Information
Module title: Pharmaceutics: Small Molecules

SCQF level: 08:
SCQF credit value: 20.00
ECTS credit value: 10

Module code: BMS08109
Module leader: Giacomo Russo
School School of Applied Sciences
Subject area group: LIFE SCIENCES
Prerequisites

N/A

Description of module content:

This module seeks to develop your understanding of the basis of organic chemistry with a focus on small molecules. After an introduction to the key concepts covering understanding of the reactions of organic compounds, including chemical bonds, valence, molecular orbitals and their interactions, you will become familiar with main functional groups (alkanes, alkenes, alkynes, alkyl halides, alcohols, aldehydes, ketones, amines, carboxylic acids, acyl derivatives along with nucleophiles and electrophiles and how to generate them for use in synthesis) in organic chemistry.

Additionally, the module provides skills to graphically represent these molecules in three dimensions and illustrate their reactions by using pieces of software routinely employed in pharmaceutical research and development. These are acquired through hands-on experience in computer labs. Building upon these concepts, fundamental properties, preparation, chemical reactivity, commercial significance, reactions, and characterisation of the main classes of molecules will be explored, with an emphasis on stoichiometry. The module looks at the transformations of key functional groups in organic chemistry, followed by an introduction to equilibrium, acids and bases, the 1st, 2nd and 3rd laws of thermodynamics.

A part of the module is devoted to tackle reaction mechanisms, introduce aromaticity and the main chemical reactions of benzene and study applications of organic chemistry.
Chemical equilibrium will be unravelled, with an emphasis on dynamic equilibrium, the constants Kc and Kp., basic calculations, extent of reaction, solubility equilibria, pH and the main aspects of thermodynamics.

Practical hands-on laboratory activities are planned to enhance your understanding and awareness of the main classes of reaction e.g., acid-base and redox titrations, assays for identifications of functional groups and chemical classes etc.

Learning Outcomes for module:

LO1:demonstrate an understanding of the main classes of chemicals and of the way of representing their structures and chemical reactions.
LO2: establish an awareness of the reactivity, preparation and commercial significance of the main classes of chemical.
LO3: show competence in the exploitation of chemical reactivity of compounds to conduct quantitative analysis and/or identify key functional groups.
LO4: show understanding of the main aspects of chemical equilibrium and reaction mechanisms of molecules of pharmaceutical interest.

Full Details of Teaching and Assessment
2022/3, Trimester 2, FACE-TO-FACE, Edinburgh Napier University
VIEW FULL DETAILS
Occurrence: 001
Primary mode of delivery: FACE-TO-FACE
Location of delivery: SIGHTHILL
Partner: Edinburgh Napier University
Member of staff responsible for delivering module: Giacomo Russo
Module Organiser:


Learning, Teaching and Assessment (LTA) Approach:
Theoretic elements will be taught using lectures supported by regular tutorial/workshops to support your understanding and allow for communication and feedback between yourselves and the teaching team (LOs 1-4). Additional materials will be provided on a weekly basis on Moodle to support clear understanding and progression.
Practical hands-on laboratory activities are planned to enhance your understanding and awareness of the main classes of reaction (LO 2, 3). Some of these will be held in the computer rooms to support use of appropriate software for 3D graphical representation of molecules. These will allow you to develop your understanding and application of good laboratory practise (GLP) and result in the maintenance of a GLP compliant scientific notebook. Skills assessed will include your knowledge and application of Health and Safety, handing of materials and equipment, chemical safety and sustainability.
One component of assessment will build on skills learned through engagement with practical sessions (including a retrosynthetic analysis of a number of small molecules and relevant discussion) (LOs 3, 4) and the other component will require application of software skills and problem-solving skills to tackle a number of case study questions (LOs 1, 2).



Formative Assessment:
Formative feedback on lab book writing and lab competencies will be provided during practical sessions and this will feed into the lab component of your assessment.
Problem-solving exercises and computer lab workshops undertaken will provide examples and formative feedback, which will support the second component of assessment, the case studies.


Summative Assessment:
The first component of assessment will build on skills you have learned through engagement with practical sessions (retrosynthetic analysis, laboratory skills competence and writing of lab book) (LOs 3, 4). The second component will require you to apply software skills and problem-solving skills to tackle a number of case study questions (LOs 1, 2).

Student Activity (Notional Equivalent Study Hours (NESH))
Mode of activityLearning & Teaching ActivityNESH (Study Hours)
Face To Face Lecture 24
Face To Face Tutorial 12
Face To Face Practical classes and workshops 18
Independent Learning Guided independent study 146
Total Study Hours200
Expected Total Study Hours for Module200


Assessment
Type of Assessment Weighting % LOs covered Week due Length in Hours/Words
Laboratory report 50 3, 4 9 , WORDS= 1000
Report 50 1, 2 14/15 , WORDS= 1000
Component 1 subtotal: 50
Component 2 subtotal: 50
Module subtotal: 100

Indicative References and Reading List - URL:
Contact your module leader