This module will build upon the concepts and understanding gained in your 1st and 2nd year physiology, genetics, and biochemistry modules, and will integrate with other 3rd year biomedical sciences modules, to develop a deeper understanding of disease mechanisms and how they may be treated. The module includes an introduction to the general principles of pharmacology, and will focus on how therapeutic drugs are administered, absorbed, distributed, metabolised and excreted by the body. Targets for therapeutic drugs will be examined, including receptor theory and dose response relationships, and the importance of drug specificity. Pathobiology is the study of how the disease arises in the first place, i.e. the disease mechanism. The pathobiology of any disease can normally be traced back to one of four main factors; genetic, environmental, pathogenic or life-style choices. Through examination of specific examples of disease you will develop a detailed knowledge of the principal causes of those diseases, and how they may be treated. The practical elements of this module will include performing a cell-based toxicity assay, and developing a protocol to compare the effectiveness of over-the-counter medications. There will also be a teamwork task, where you will be asked to produce a scientific website designed to give patients and health care practitioners information on the pathology of a particular disease and the molecular mechanisms of current treatment options. Throughout the module, you will be expected to engage with primary research literature.