This module will build upon concepts and knowledge gained in 1st and 2nd year modules to discuss the internal organisation of the cell and how it responds to intracellular and extracellular cues. There will be 4 main overarching topics covered in this module: membrane function and receptors, cell signalling cascades, protein biochemistry, cellular structures and compartments.In particular you will study membrane function; receptor based communication and their signalling networks; the importance of protein interactions and post-translational modifications in cell signalling pathways; their impact on protein function, targeting and turnover. These will be discussed in the context of the relevant cellular compartments and structures. The course will discuss these concepts and mechanisms through major cellular processes such as cell division and cell death.You will be taught through lectures, tutorials and workshops. You will also undertake practical activities in the laboratory and will be assessed on your ability to plan and execute these experiments and interpret and present the data you obtain. A substantial amount of time has been set aside for self-directed study to reflect the fast moving pace of this field and the need to consult the literature, to prepare for tutorials, workshops and practical classes.