Module title: Molecular Genetics (Sri Lanka)

SCQF level: 09:
SCQF credit value: 20.00
ECTS credit value: 10

Module code: BMS09803
Module leader: Arthur Robinson
School School of Applied Sciences
Subject area group: Biomedical Science
Prerequisites

There are no pre-requisites for this module to be added

2019/0, Trimester 1, Face-to-Face, Edinburgh Napier University
Occurrence: 001
Primary mode of delivery: Face-to-Face
Location of delivery: SRI LANKA
Partner: Edinburgh Napier University
Member of staff responsible for delivering module: Arthur Robinson
Module Organiser:


Learning, Teaching and Assessment (LTA) Approach:
Learning & Teaching methods including their alignment to LOs
Lectures cover LOs 1 – 4 and are supported by tutorials, while LO5 is covered by laboratory work, for which guidance is given and marking criteria are advised. Questioning is encouraged during tutorials, on-line using Moodle discussion forums, and in laboratory classes. Personalised feedback is given during tutorials and for the laboratory report.

Embedding of employability/PDP/Scholarship Skills
Five key employability skills are embedded. Critical thinking and written communication skills are required in the tutorial work, the coursework component and examination. Group work and oral communication skills are required for both tutorial work and the laboratory component. IT skills are required for the use of Moodle and for on-line searches associated with the preparation/submission of coursework (laboratory report). Scholarship skills are required for the directed reading associated with the subject material. Critical thinking is required for commenting on and analysing laboratory data.

Research / teaching linkages
Students are directed (either through Moodle or during tutorials/laboratory classes) to supporting web sites. These may include animations of key molecular processes.

Supporting equality and diversity
Materials are provided in both hard and soft (Moodle) formats to ensure that they are available to all students.

Formative Assessment:
Tutorials will include elements of formative assessment, while summative assessment takes the form of coursework: a laboratory report (LO5), problem solving during Moodle tests (LOs 1 - 4), and a formal examination (LOs 1 - 4). A 3 hour examination is required to allow students to complete data analysis/interpretation questions. Feedback on the laboratory report is given in stages so that students have an opportunity to improve their performance in subsequent reports in other modules.

Summative Assessment:
Tutorials will include elements of formative assessment, while summative assessment takes the form of coursework: a laboratory report (LO5), problem solving during Moodle tests (LOs 1 - 4), and a formal examination (LOs 1 - 4). A 3 hour examination is required to allow students to complete data analysis/interpretation questions. Feedback on the laboratory report is given in stages so that students have an opportunity to improve their performance in subsequent reports in other modules.

Student Activity (Notional Equivalent Study Hours (NESH))
Mode of activityLearning & Teaching ActivityNESH (Study Hours)
Face To Face Lecture 22
Face To Face Tutorial 8
Face To Face Practical classes and workshops 12
Independent Learning Guided independent study 155
Face To Face Centrally Timetabled (Digital) Exam 3
Total Study Hours200
Expected Total Study Hours for Module200


Assessment
Type of Assessment Weighting % LOs covered Week due Length in Hours/Words
Digital Examination (not Centrally Timetabled) 30 1-4 2 HOURS= 0, WORDS= 0
Practical Skills Assessment 20 5 9 HOURS= 0, WORDS= 800
Centrally Time Tabled Examination 50 1-4 14/15 HOURS= 3, WORDS= 0
Component 1 subtotal: 50
Component 2 subtotal: 50
Module subtotal: 100

Description of module content:

Revision of structure, and function of DNA and RNA, and of the genetic code. Induction and genotypic classification of mutations, and their consequences (phenotypic effects). DNA repair (direct, excision, mismatch correction, recombination and “error-prone”). Genetic recombination, bacterial conjugation, and role of the F plasmid in gene transfer. Mapping of chromosomal markers by interrupted mating. Transformation. Transduction. Restriction enzymes and restriction mapping. Cloning DNA sequences using plasmid and bacteriophage vectors. Developments in vector technology. cDNA cloning. Identification of specific clones of interest. Analysis/manipulation of DNA sequences by: polymerase chain reaction (PCR), DNA sequencing, site-directed mutagenesis, and Southern blotting. Regulation of gene expression in prokaryotic and eukaryotic organisms.

Learning Outcomes for module:

Upon completion of this module you will be able to
LO1: Compare and contrast mechanisms of mutation, DNA repair, and DNA transfer in Escherichia coli, and derive genetic maps from gene transfer data.
LO2: Determine the genetic and molecular basis of restriction/modification systems and derive restriction maps by interpreting both theoretical and laboratory data.
LO3: Interpret the laboratory principles of gene cloning: the identification, selection and amplification of specific DNA sequences, and the generation of genomic libraries.
LO4: Evaluate the techniques of gene expression analysis and gene function.
LO5: Carry out laboratory transfers, manipulations and analyses of DNA.

Indicative References and Reading List - URL:

Core - HARTL, DL (2014) ESSENTIAL GENETICS - A GENOMICS PERSPECTIVE: JONES & BARTLETT LEARNING, 6th ed. - ISBN: 9781449686888
Core - MCLENNAN, A, BATES, A, TURNER,P & WHITE, M (2013) BIOS INSTANT NOTES MOLECULAR BIOLOGY: GARLAND SCIENCE, 4th ed. - ISBN: 9780415684163
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