Module title: Applied Toxicology (Hong Kong)

SCQF level: 10:
SCQF credit value: 20.00
ECTS credit value: 10

Module code: BMS10601
Module leader: Jenny Fraser
School School of Applied Sciences
Subject area group: Biomedical Science
Prerequisites

ENV09600 Environmental Toxicology (Hong Kong)

2018/9, Trimester 2, Blended,
Occurrence: 001
Primary mode of delivery: Blended
Location of delivery: HONG KONG
Partner:
Member of staff responsible for delivering module: Peter Barlow
Module Organiser:


Learning, Teaching and Assessment (LTA) Approach:
Learning & teaching methods including their alignment to LOs
Introductory Lectures and tutorial sessions together with study material provided by Moodle will cover LOs 1 – 5. This will be supported by face-to-face lectures and tutorials delivered by local tutors, during which students work in small groups to undertake exercises to develop skills in critical and independent thinking. The assessment strategy is outlined in weeks 1/2 both in a written and verbal format in order to allow students the opportunity to ask questions and provide feedback. Material provided on Moodle and in class will direct the students to a series of tasks or activities that require the students to develop and assimilate the information provided and develop their skills of critical analysis, data analysis, hypothesis generation and study design. Feedback is provided to individual students and to the group as a whole on completion of the task. These skills are subsequently assessed along with scientific understanding in the exam. Discussion will be encouraged during face-to-face teaching in both lectures and tutorials, and on-line using the discussion boards.



Formative Assessment:
Formative assessment occurs on a weekly basis by provision of tasks to complete during class and/or via Moodle.

Summative Assessment:
Summative assessment occurs in weeks 10 and 14, with the completion of a multiple choice test in week 10 and in week 14/15 a formal examination taking the form of interpretation and critical analysis of published data and literature. The students are provided with a copy of the research publication in week 11 in order to allow accessibility. Answers must not only illustrate understanding of the subject matter, but also ability to think and research outside of the lecture content by providing evidence of independent research and reading, as well as critical analysis.

Student Activity (Notional Equivalent Study Hours (NESH))
Mode of activityLearning & Teaching ActivityNESH (Study Hours)
Face To Face Lecture 4
Face To Face Tutorial 12
Online Guided independent study 60
Independent Learning Guided independent study 121
Face To Face Centrally Time Tabled Examination 3
Total Study Hours200
Expected Total Study Hours for Module200


Assessment
Type of Assessment Weighting % LOs covered Week due Length in Hours/Words
Digital Examination (not Centrally Timetabled) 30 1,2,3 10 HOURS= 1, WORDS= 0
Centrally Time Tabled Examination 70 1-5 14/15 HOURS= 3, WORDS= 0
Component 1 subtotal: 30
Component 2 subtotal: 70
Module subtotal: 100

Description of module content:

Introduction to human toxicology. Toxicokinetics and toxicodynamics. Organ-specific toxicity and pathophysiology. Cellular and molecular mechanisms of xenobiotic toxicity. Toxicogenomics. Hazard and risk assessment. Detailed descriptions of specific toxicant examples, such as alcohol, metals, air pollutants, and endocrine disruptors. In utero exposure and prenatal programming. In vitro and in vivo models of toxicity.

Learning Outcomes for module:

LO1: Conceptualise the relationship between absorption, distribution, metabolism, and excretion of major drugs and xenobiotics.
LO2: Evaluate the importance and role of dose-response relationships in toxicology.
LO3: Critically appraise the available models for toxicity assessment and the applicability and limitations of each
LO4: Discriminate the major target organs for xenobiotics and illustrate some of the associated effects in liver, lungs, skin, reproductive system, and nervous system.
LO5: Critically assess the effects of in utero exposure to environmental stimuli in relation to prenatal programming.

Indicative References and Reading List - URL:

Core - ALBERTS, B.,JOHNSON, A., LEWIS, J., RAFF, M., ROBERTS, K., AND WALTER, P (2008) MOLECULAR BIOLOGY OF THE CELL: GARLAND SCIENCE, 5th ed. - ISBN: 0815332181
Core - BOELSTERLI UA (2007) MECHANISTIC TOXICOLOGY: THE MOLECULAR BASIS OF HOW CHEMICALS DISRUPT BIOLOGICAL TARGETS.: CRC PRESS, 2nd ed. - ISBN: 9780849372728
Core - MICHAEL D COLEMAN (2010) HUMAN DRUG METABOLISM : AN INTRODUCTION: WILEY, 2nd ed. - ISBN: 9780470742174
Core - H P RANG (2012) RANG AND DALE'S PHARMACOLOGY:: CHURCHILL LIVINGSTONE, 7th ed. - ISBN: 9780702034718
Core - LESLEY STANLEY (2014) MOLECULAR AND CELLULAR TOXICOLOGY: AN INTRODUCTION: WILEY BLACKWELL, 1st ed. - ISBN: 9781119952
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