Module title: Drug Design and Chemotherapy

SCQF level: 11:
SCQF credit value: 20.00
ECTS credit value: 10

Module code: BMS11105
Module leader: David Mincher
School School of Applied Sciences
Subject area group: Microbiology & Drug Discovery
Prerequisites

There are no pre-requisites for this module to be added

2019/0, Trimester 2, Face-to-Face, Edinburgh Napier University
Occurrence: 001
Primary mode of delivery: Face-to-Face
Location of delivery: SIGHTHILL
Partner: Edinburgh Napier University
Member of staff responsible for delivering module: David Mincher
Module Organiser:


Learning, Teaching and Assessment (LTA) Approach:
A series of lectures will afford students with central information and present contemporary examples in Drug Design to stimulate interest and independent learning activities (LOs 1,2,4). Guest lecturers from the pharmaceutical and healthcare professional industries provide students with insights into drug design in practice by covering scientific, economic and ethical aspects (LOs 1,2). Carefully designed interactive tutorials and molecular graphics workshops and laboratory exercises (LO3) stimulate learning by developing problem-solving and presentational skills; the group nature of some of these activities also develops communication and organizational attributes.
Laboratory work is designed to parallel techniques adopted in the industry and, in conjunction with the tutorial programme, to allow students the opportunity to solve problems individually and in team exercises. Incisive thinking and critical appraisal, communication and organisational skills are systemically embedded.
The module is designed to emphasize that progress in drug design is intrinsically research-driven. The module is delivered by research-aware and research-active staff, supported by industry-based research expertise. Students are given instruction on Literature.
The module is supported by a VLE (Moodle) which is used to provide class materials (including lectures, tutorials, workshops and laboratory classes), resource such as animations, videos, direct links to relevant web-based resource, e:submission of all coursework, self-assessment test, interactive teaching resource, and independent study materials to cover expected prior-learning. Reflecting the discipline, students use a wide range of technology to accomplish laboratory work and in silico analysis.


Formative Assessment:
Provision is made for formative assessment and feedforward in the analysis and evaluation of data generated in the tutorial and workshops sessions (individual and group-based activities) where continuous feedback is provided by staff members, allowing time for reflection and revision of solutions to problems set.

Summative Assessment:
Summative assessments take the form of an examination (LOs 1,2,4) which assesses overall level of knowledge and understanding of drug design principles applied at the interface of medicinal chemistry and molecular biology; and assessed laboratory reports, prepared to research publication standards (LO3).

Student Activity (Notional Equivalent Study Hours (NESH))
Mode of activityLearning & Teaching ActivityNESH (Study Hours)
Face To Face Lecture 22
Face To Face Tutorial 9
Face To Face Practical classes and workshops 21
Independent Learning Guided independent study 145
Face To Face Centrally Time Tabled Examination 3
Total Study Hours200
Expected Total Study Hours for Module200


Assessment
Type of Assessment Weighting % LOs covered Week due Length in Hours/Words
Report 20 3 10 HOURS= 0, WORDS= 1000
Centrally Time Tabled Examination 80 1,2,4 13 HOURS= 3, WORDS= 0
Component 1 subtotal: 20
Component 2 subtotal: 80
Module subtotal: 100

Description of module content:

The module is focussed on the chemical principles of drug design of new chemotherapeutic agents in relation to the identification and validation of emerging biological molecular targets. The emphasis is on major classes of life-threatening disease: notably, cancer; viral and resistant bacterial infection. You will learn to evaluate existing and new biological targets and contemporary drug design methods (chemical and biological) to combat these disease states. You will develop the skills required to conduct searching laboratory experiments and to produce written scientific reports to research publication standards. You will benefit from industry-based guest-lecturer input, in support of integrated lectures, tutorials, workshops, molecular modelling activities designed to develop your key skills and confidence necessary to work and progress in the field of drug research.
Emphasis on: molecular targets in cancer: characterisation and structure of biological targets (genes; enzymes; receptors; nucleic acids). Design, synthesis and mechanism of action of inhibitors of telomerase, the G-quadruplex, DNA-topoisomerases, matrix metalloproteinases. Targeted therapies, drug delivery mechanisms, design of prodrugs; macromolecular prodrugs and nanoconjugates. Synthetic oligonucleotides, PNAs, DNA-and RNA-binding ligands: design and applications. Synthesis and development of non-nucleoside antiviral agents: HIV integrase inhibitors, protease inhibitors. Peptoids and peptide mimics. Mechanisms of intrinsic and acquired drug resistance and MDR. Contemporary drug design to combat resistant bacterial and protozoal infections.
Laboratory work in selected drug synthesis, methods of purification and characterisation; solution and solid- phase combinatorial peptide methodology and biological (including enzyme) assays; molecular graphics.

Learning Outcomes for module:

Upon completion of this module you will be able to
LO1: Critically review and appraise the detailed chemistry and design of contemporary anticancer, antiviral and antibacterial agents.
LO2: Evaluate drug mechanisms of action; molecular biological targets and therapeutics.
LO3: Analyse and present the results of laboratory experiments to research publication standards and critically evaluate the data in the context of the prior and contemporary literature.
LO4: Critically evaluate the design of macromolecular and nanoparticulate prodrug delivery systems.

Indicative References and Reading List - URL:
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