This module will build upon the pharmacokinetic principles of ADME (absorption, distribution, metabolism and elimination) and bioavailability (F) to allow you to appraise how different medicine design affects these parameters.We will critically evaluate how different formulation additives, route of administration and release kinetics (Immediate release, sustained release, targeted release) can impact not only on the pharmacokinetic profile of a drug, but also the doses and the dosing regimen used. We will explore factors that influence the rate and extent of drug absorption which include food-drug interactions. We will critically review and reflect on the use of key analytical and bioanalytical techniques to assess drug concentration within the body and its application in therapeutic drug monitoring (TDM) and dose adjustment. You will learn how to interpret different representations of data such as plasma concentration time curves and urinary drug excretion curves. You will also gain a commercial awareness of medicine manufacture processes (e.g. coatings) and the value of elements such as tablet size, colour and packaging. We will also tackle the biologics market, where medicines are manufactured using recombinant DNA technology. In the labs you will learn about experimental design, preformulation tests such as Log P (Partition coefficient) determination and use of instrumental analytical techniques such as UV/VIS assays in preformulation testing. In the labs you will also be required to maintain a Good Laboratory Practice (GLP) compliant lab book.