Module title: Applications of Molecular Biology (Sri Lanka)

SCQF level: 10:
SCQF credit value: 20.00
ECTS credit value: 10

Module code: MIC10805
Module leader: Nicole Payton
School School of Applied Sciences
Subject area group: Biomedical Science

To study this module you will need the learning equivalent to the module listed below or have passed this module:

BMS09803 Molecular Genetics [Sri Lanka]

2018/9, Trimester 1, Blended,
Occurrence: 001
Primary mode of delivery: Blended
Location of delivery: SRI LANKA
Member of staff responsible for delivering module: Nicole Payton
Module Organiser:

Learning, Teaching and Assessment (LTA) Approach:
Introductory lectures and tutorial sessions together with study material provided by VLE/ Moodle will cover LOs1-5. This will be supported by face-to-face lectures and tutorials delivered by local tutors, during which students work in small groups to undertake exercises in experiment design, problem-solving or critiquing a paper. Questioning is encouraged during face-to-face teaching in both lectures and tutorials, and on-line using the discussion boards. Elements of LO4 are covered by a combination of on-line learning and a coursework assignment. Personalised feedback is given on the coursework component (bioinformatics report).

Formative Assessment:
Tutorials will include elements of formative assessment.

Summative Assessment:
Summative assessment takes the form of coursework (LO4) and a formal examination (LOs 1 - 5). A 3 hr examination is required to allow students to complete data analysis/interpretation questions.

Student Activity (Notional Equivalent Study Hours (NESH))
Mode of activityLearning & Teaching ActivityNESH (Study Hours)
Face To Face Lecture 4
Face To Face Tutorial 12
Online Guided independent study 60
Independent Learning Guided independent study 121
Face To Face Centrally Time Tabled Examination 3
Total Study Hours200
Expected Total Study Hours for Module200

Type of Assessment Weighting % LOs covered Week due Length in Hours/Words
Centrally Time Tabled Digital Examination 60 1,2,3,4 & 5 14/15 HOURS= 3, WORDS= 0
Report 40 4 10 HOURS= 0, WORDS= 1000
Component 1 subtotal: 60
Component 2 subtotal: 40
Module subtotal: 100

Description of module content:

Analysis of eukaryotic and prokaryotic genome organisation. Identification/classification of repetitive DNA sequences on human genome structure and evolution. Mini-satellite DNA and short tandem repeats (STRs). DNA sequences as unique identifiers: DNA profiling in forensic science. Genomics and proteomics – technologies and application; Microarray technology and applications; Bioinformatics – use of databases and tools for comparison of DNA and protein sequences. PCR and protein engineering – PCR-based genetic engineering techniques, qualitative, semi-quantitative and quantitative PCR, real-time PCR, applications in molecular analysis. Gene cloning and expression in heterologous hosts – technology, applications, identification of potential problems associated with expressing proteins in foreign hosts. Recombinant DNA technology - cloning vectors, expression vectors, reporter systems, applications in biotechnology and medical research.

Learning Outcomes for module:

Upon completion of this module you will be able to:
LO1: Analyse and interpret features of genome organisation.
LO2: Compare and contrast the properties, distribution and behaviour of different DNA sequence elements found in the human genome and evaluate the applications of this knowledge in biomedical and forensic laboratories.
LO3: Critically appraise PCR, and “omics” technologies and their applications in the analysis of genomes and gene expression.
LO4: Analyse and interpret data from DNA sequencing, microarrays and PCR analysis.
LO5: Compare and contrast strategies for gene cloning and genetic engineering, including heterologous gene expression.

Indicative References and Reading List - URL:

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