Core Module Information
Module title: Cell Technology

SCQF level: 11:
SCQF credit value: 20.00
ECTS credit value: 10

Module code: MIC11103
Module leader: Fiona Stainsby
School School of Applied Sciences
Subject area group: Microbiology & Drug Discovery
Prerequisites

N/A

Description of module content:

In this module you will be introduced to various methods and approaches to cell culture, preservation and manipulation including for example microbial, plant, human/animal primary and/or immortalised cell lines. Various aspects of cell handling will be explored including media design, isolation and purification, sterility, inoculum development, and cell counting. You will also examine various approaches to cell manipulation and strain improvement for bioprocessing e.g. genetic modification, stress fermentation through case studies.
The units of operation of a bioprocess and factors influencing optimisation will be appraised including bioreactor design, mode of operation, scale-up, and product separation and analysis.
Both theoretical and applied aspects of fermentation growth kinetics will also be considered.
You will also explore important commercial aspects of cell technologies including regulatory requirements and quality assurance processes: COSSH, GMP, GLP, biosafety and containment, as well as product approval, validation and auditing.
Laboratory experiments and/or demonstrations will relate to theoretical aspects of cell technology and bioprocessing and will cover cell culture methods, media preparation, fermentation set-up, operation and monitoring, product separation and analysis, experimental design and data-handling.

Learning Outcomes for module:

LO1: Appraise methods for culture, preservation, and manipulation of microorganisms and mammalian cell lines that are utilised in cell technologies.

LO2: Critically appraise the factors impacting on the optimisation of bioprocesses, including the cell type, fermentation conditions, and product separation procedures.

LO3: Critically reflect on the regulatory and quality assurance frameworks of relevance to bioprocessing and other cell technologies.

LO4: Evaluate the design and operational parameters of a bioprocess that influence the synthesis and nature of the biological entities involved.

LO5: Determine the efficiency of product formation and output in a bioprocess using appropriate handling and interpretation of growth kinetics data.

Full Details of Teaching and Assessment
2021/2, Trimester 1, FACE-TO-FACE,
VIEW FULL DETAILS
Occurrence: 001
Primary mode of delivery: FACE-TO-FACE
Location of delivery: SIGHTHILL
Partner:
Member of staff responsible for delivering module: Fiona Stainsby
Module Organiser:


Learning, Teaching and Assessment (LTA) Approach:
This module will be delivered through a combination of face-to-face lectures, tutorials and practical classes. All lectures and tutorial sessions (LO1-5) will include interactive components during which you will work individually and in small groups to undertake exercises in data-handling and interpretation, critical analysis and report writing (LO2). Laboratory sessions will be used to develop various key practical skills including handling of microbial and mammalian cell cultures (LO1), use of various equipment used in biotechnology including the bench-top fermenter (LO4/LO5) and will be designed to enhance your skills in working with precision and reproducibility.


Formative Assessment:
You will have various opportunities to engage in interactive exercises during lectures, tutorials and laboratory classes and be given immediate feedback on your contributions. These will be designed to support preparation for the summative assessments.

Summative Assessment:
The summative assessment for this module consists of two components.
Component 1, a test [held in week 7] will assess theoretical knowledge of bioprocessing and growth kinetics as well as data-handling and interpretation skills [LO4 & LO5/ 40% weighting].
The second component [due for submission in week 13] is a critical review of a cell technology either under research and development or at full commercial scale [LO1,LO2 & LO3/60% weighting].


Student Activity (Notional Equivalent Study Hours (NESH))
Mode of activityLearning & Teaching ActivityNESH (Study Hours)
Face To Face Lecture 11
Face To Face Tutorial 18
Face To Face Practical classes and workshops 21
Independent Learning Guided independent study 150
Total Study Hours200
Expected Total Study Hours for Module200


Assessment
Type of Assessment Weighting % LOs covered Week due Length in Hours/Words
Class Test 40 4,5 7 HOURS= 03.00, WORDS= 0
Report 60 1,2,3 13 HOURS= 00.00, WORDS= 2500
Component 1 subtotal: 40
Component 2 subtotal: 60
Module subtotal: 100

Indicative References and Reading List - URL:
Contact your module leader